Fiorentina will look to Moise Kean and potentially Edoardo Bove for the showdown with Inter’s Lautaro Martinez and Marcus Thuram.
It kicks off at the Stadio Artemio Franchi on Sunday at 17.00 GMT.
These teams are both tied together in joint second place alongside Atalanta and Lazio going into the weekend, just one point shy of leaders Napoli.
Fiorentina are one of the form teams in Serie A right now thanks to seven consecutive victories and bring back their star men after squad rotation in Thursday’s 3-2 Conference League win over Pafos.
That means Kean upfront, though Albert Gudmundsson should at most only be fit for a spot on the bench.
Yacine Adli returns to midfield and we could see former Roma midfielder Bove in the trequartista role behind the striker.
Inter make the trip without injured Francesco Acerbi, Benjamin Pavard and Carlos Augusto, but the good news is that Davide Frattesi has shaken off a knock to be part of the squad.
He won’t start, as Henrikh Mkhitaryan and Hakan Calhanoglu form the usual midfield, but Denzel Dumfries is battling Matteo Darmian to play on the right.
There isn’t much choice in defence, as Yann Bisseck and Stefan de Vrij come in, while Lautaro Martinez will partner Thuram upfront.
Fiorentina vs. Inter probable line-ups
Fiorentina (4-2-3-1): De Gea; Dodô, Comuzzo, Ranieri, Gosens; Adli, Cataldi; Colpani, Beltran, Bove; Kean
Inter (3-5-2): Sommer; Bisseck, De Vrij, Bastoni; Dumfires, Barella, Calhanoglu, Mkhitaryan, Dimarco; Lautaro Martinez, Thuram
