Dusan Vlahovic returns to lead the Juventus attack during an injury crisis, while Bologna must do without Riccardo Orsolini.
It kicks off at the Allianz Juventus Stadium at 17.00 GMT.
The Bianconeri have stuttered in recent weeks both in Serie A and Europe amid an injury crisis, which continues to rule out Weston McKennie, Nico Gonzalez, Douglas Luiz, Arkadiusz Milik, Gleison Bremer and Juan Cabal.
There is at least some good news for coach Thiago Motta, facing his former team, because Vlahovic, Nicolò Savona and Vasilije Adzic return to the squad.
Kenan Yildiz is rested ahead of the big Champions League clash with Manchester City on Wednesday.
They need to focus here, because they risk sliding too far from the top of the table after drawing eight of their last 12 Serie A games.
Bologna won four of their last five Serie A matches, capitulating only to Lazio when down to 10 men.
They also have a game in hand, as the fixture with Milan was called off due to flood warnings.
Tommaso Pobega returns from suspension, but Orsolini has been ruled out for three weeks after the midweek 4-0 Coppa Italia victory over Monza.
Michel Aebischer, Charalampos Lykogiannis, Oussama El Azzouzi and Nicolò Cambiaghi are also out of action.
Dan Ndoye and Jens Odgaard help support Santiago Castro upfront with intriguing 21-year-old Benjamin Dominguez.
Juventus: Perin; Danilo, Gatti, Kalulu, Cambiaso; Locatelli, Fagioli; Conceicao, Koopmeiners, Weah; Vlahovic
Bologna: Skorupski; Holm, Beukema, Lucumì, Miranda; Freuler, Pobega; Ndoye, Odgaard, Dominguez; Castro
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