The Falcons ruled out inside linebacker Nate Landman and defensive back Antonio Hamilton Sr. for Monday Night Football.
Landman had a quad injury late in the preseason but played in the season opener. He saw action on 54 percent of the defensive snaps and had a crucial fourth-and-one stop in the fourth quarter.
Landman, though, also now has a calf injury and did not participate in practice this week.
The Falcons have only rookie JD Bertrand behind starters Kaden Elliss and Troy Andersen and do not have a true inside linebacker on the practice squad. They did workout veteran linebackers Kwon Alexander, Rashaan Evans and Josh Woods on Friday.
Hamilton will miss his second consecutive game with a groin injury as he returned to limited practices Friday and Saturday.
Offensive tackle Kaleb McGary (groin) and running back Jase McClellan (knee) were full participants Saturday and neither has a designation.