Artem Dovbyk, Matias Soulé and Lorenzo Pellegrini start as Roma try to find their feet under Ivan Juric without Paulo Dybala, visiting Daniel Maldini’s Monza.
It kicks off at the U-Power Stadium at 17.00 UK time (16.00 GMT).
The Giallorossi have had a mixed bag under their new coach and fans continue their protests, albeit with less ferocity being away from home.
While they won all three Serie A matches, there were big problems in the Europa League, drawing 1-1 with Athletic Club and losing 1-0 at Elfsborg on Thursday.
Dybala sustained a muscular injury and is out of action, while Mats Hummels has flu, along with long-term absentees Enzo Le Fée and Alexis Saelemaekers.
Pellegrini returns to the starting XI to support Soulé and Dovbyk.
With the number of absentees and contract talks on-going, Nicola Zalewski returns to the bench for the first time since rejecting a transfer to Galatasaray.
Monza are looking for their first win of the campaign and have a serious injury crisis for coach Alessandro Nesta.
Andrea Petagna and Stefano Sensi joined Alessio Cragno, Patrick Ciurria, Roberto Gagliardini and Samuele Vignato on the treatment table.
Even Stefano Turati is out with a bruise, so Samuele Pizzignacco gets a rare start in goal as their third choice.
Dany Mota Carvalho is not fully fit either, so Maldini celebrates his senior Italy call-up by starting with Milan Djuric and Matteo Pessina.
Monza: Pizzignacco; Izzo, Marì, A Carboni; Pereira, Bianco, Bondo, Kyriakopoulos; Maldini, Pessina; Djuric
Roma: Svilar; Mancini, N’Dicka, Angelino; Celik, Cristante, Koné, El Shaarawy; Soulè, Pellegrini; Dovbyk
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