Announcing his decision in an interview with Nasser Hussain, external in the Daily Mail, Moeen said it was “time for the next generation” in English cricket.
“I could hold on and try to play for England again, but I know in reality I won’t,” Moeen said.
“Even retiring, I don’t feel it’s because I’m not good enough – I still feel I can play.
“But I get how things are, and the team needs to evolve into another cycle. It’s about being real to myself.”
A stylish left-handed batter, Moeen scored five Test and three ODI centuries.
He also took 204 Test wickets, along with 111 in ODIs and 51 in T20 cricket for England.
His final international appearance was against India in the semi-finals of the T20 World Cup in June, which England lost by 68 runs.
