Moise Kean and Giacomo Raspadori are the new strike partners with a few other adjustments, but Sandro Tonali still pulls the strings as Italy face Israel in the Nations League.
It kicks off on neutral turf at the Boszik Arena in Budapest at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Azzurri conceded their fastest ever goal in Paris after 14 seconds, but came back to beat France 3-1 on Friday.
Riccardo Calafiori and Lorenzo Pellegrini picked up injuries and are ruled out here, so Alessandro Buongiorno and Federico Gatti step into the defence.
Raoul Bellanova replaces Andrea Cambiaso on the right wing, with Raspadori and Kean the new strike partners upfront.
Tonali had an exceptional performance against France and again forms the core of the midfield with Davide Frattesi and Torino’s Samuele Ricci.
Israel were beaten 3-1 by Belgium on Friday, despite Loic Openda seeing a penalty saved by third-choice goalkeeper Yoav Gerafi.
He is starting again, because Daniel Peretz and Omri Glazer are both injured.
Gavriel Kanichowsky, Roy Revivo and Dor Peretz all step into the starting XI, but the star men are Leeds United’s Manor Solomon and RB Salzburg talent Oscar Gloukh.
Israel vs. Italy line-ups
Israel: Gerafi; Revivo, Shlomo, Nachmias, Jehezkel; Kanichowsky, Lavi, Abada, Dor Peretz; Solomon, Khalaili
Italy: Donnarumma; Gatti, Buongiorno, Bastoni; Bellanova, Frattesi, Ricci, Tonali, Dimarco; Raspadori, Kean
Ref: Kruzliak (SVK)
