Inter trust Lautaro Martinez and Marcus Thuram in the Supercoppa Italiana semi-final, while Atalanta totally revamp with Lazar Samardzic and Nicolò Zaniolo upfront.
It kicks off at the Al-Awwal Park Stadium in Riyadh at 19.00 GMT.
You can follow all the build-up and action as it happens on the Liveblog.
The tournament takes the Final Four format, as today the Serie A holders face the Coppa Italia runners-up, then tomorrow Milan who were second in the Scudetto race will play Cup winners Juventus.
The Final is then on Monday evening, as Inter try to win the Supercoppa for the fourth year in a row.
If the teams are level after 90 minutes, they go straight to a penalty shoot-out, so there will be no extra time.
Inter have limited options in defence, as Francesco Acerbi and Benjamin Pavard did not make the trip, but Matteo Darmian is available again.
Lautaro Martinez and Marcus Thuram lead the attack, with Hakan Calhanoglu and Federico Dimarco in support.
Atalanta are top of the Serie A table, despite seeing their 11-match winning streak ended by a draw with Lazio, but lost 4-0 to Inter back in August.
La Dea have not beaten Inter since a 4-1 result in November 2018, managing just five draws in their last 13 competitive meetings.
Mateo Retegui, Juan Cuadrado and Gianluca Scamacca are all out of action, so there has to be a False 9 in attack.
Surprisingly, Charles De Ketelaere and Ademola Lookman are on the bench, with Marco Brescianini and Samardzic supporting Zaniolo.
Defender Giorgio Scalvini also seems to be moved into midfield.
Inter vs. Atalanta line-ups
Inter: Sommer; Bisseck, De Vrij, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Lautaro Martinez
Atalanta: Carnesecchi; Kossounou, Hien, Kolasinac; Zappacosta, De Roon, Scalvini, Ruggeri; Brescianini, Samardzic; Zaniolo
Ref: Chiffi
